During her college career with Virginia from 1988 to 1992, Staley set the NCAA record for steals, the school record for points, and the ACC record for assists. She played professionally in the American Basketball League (ABL) during its three years of operation before being selected ninth overall by the Sting in the 1999 WNBA draft. As a member of the Sting and the Houston Comets, she received six consecutive WNBA All-Star selections from 2001 to her final season in 2006. Staley spent most of her WNBA career simultaneously serving as the head coach of the Temple Owls

women’s basketball team from 2000 to 2008, leading them to six NCAA tournaments, three regular-season conference championships, and four conference tournament titles.
After becoming South Carolina’s head coach in 2008, Staley rebuilt the Gamecocks into one of the top women’s basketball programs. During her 16 seasons, she has led South Carolina to eight SEC regular season championships, eight SEC tournament championships, eight Sweet Sixteens, five Final Fours, and three NCAA women’s basketball national championships, including the school’s first in 2017 and a perfect season in 2024. Staley was inducted to the Women’s Basketball Hall of Fame in 2012 and the Naismith Memorial Basketball Hall of Fame in 2013.